Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson's Disease
Journal of Movement Disorders
;
: 69-79, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-38089
ABSTRACT
Parkinson's disease (PD), the second most common neurodegenerative disorder after Alzheimer's disease, is characterized by the loss of nigral dopaminergic neurons. PD leads to a series of clinical symptoms, including motor and non-motor disturbances. α-synuclein, the major component of Lewy bodies, is a hallmark lesion in PD. In this review, we concentrate on presenting the latest research on the structure, distribution, and function of α-synuclein, and its interactions with PD. We also summarize the clinic applications of α-synuclein, which suggest its use as a biomarker, and the latest progress in α-synuclein therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Corpos de Lewy
/
Doenças Neurodegenerativas
/
Alfa-Sinucleína
/
Neurônios Dopaminérgicos
/
Doença de Alzheimer
Idioma:
Inglês
Revista:
Journal of Movement Disorders
Ano de publicação:
2017
Tipo de documento:
Artigo
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