Effects of Xuebijing injection on inflammatory response in patients with acute respiratory distress syndrome / 中国基层医药

ABSTRACT

Objective To evaluate the effects of Xuebijing injection on inflammatory response in patients with acute respiratory distress syndrome(ARDS) by the changes of the level of PCT in bronchoalveolar lavage fluid (BALF) and plasma so as well as serum tumor necrosis factor-α(TNF-α) 、interleukin-6(IL-6) and interleukin-8( IL-8). Methods Sixty patients treated at the intensive care unit(ICU) were recruited in this study;these subjects satisfied the diagnostic criteria for ARDS. They were randomly classified into two groups study group ( 30 patients) in which patients were given Xuebijing injection 100ml and 5% Glucose injection 150 ml daily,and control group(30 patients) patients were given 5% Glucose injection 250ml daily. The changes of the level of PCT in BALF and plasma so as well as serum TNF-α,IL-6 and IL-8 were monitored before intervention and seven days later. Results The level of PCT in BALF and plasma before intervention were statistically higher than normal( t= 2.882、2.657 all P ＜0.01 )while decreased significantly seven days later ( all P ＜ 0.01 ) in study group but fewer change in control group ( all P ＞0.05 ). Levels of TNF-α,IL-6 and IL-8 were statistically higher than normal before intervention( all P ＜ 0.05 ) while decreased significantly seven days later( all P ＜0.01 )in study group but fewer change in control group( all P ＞0.05 ). The mortality of patients was 26.7% ( study group) and 33.3% ( control group) ( all P ＜ 0.05 ) respectively.Conclusion Xuebijing injection could lower the level of PCT in BALP and plasma of patients with ARDS,played the role of antiinflammatory and improving the oxygenation, and could to reduce the mortality of patients.