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Design, synthesis and antiepileptic activity of 4-(2-acetoxybenzoylamino) butyrate derivatives / 药学学报
Acta Pharmaceutica Sinica ; (12): 299-304, 2011.
Article em Zh | WPRIM | ID: wpr-382415
Biblioteca responsável: WPRO
ABSTRACT
A series of 4-(2-acetoxybenzoylamino) butyrate derivatives were designed and synthesized. All of the novel 12 compounds (7a-7k) were synthesized from gamma-aminobutyric acid (1) as starting material, and their structures were confirmed with IR, 1H NMR, EI-MS and elemental analysis. Preliminary pharmacological test in vitro showed that most of these title compounds possessed antiepileptic activity. Compounds 7i-7k displayed strong antiepileptic activity and are worth for further development. Compounds 4, 7d-7h showed moderate antiepileptic activity. The structure-activity relationship of 4-(2-acetoxybenzoylamino) butyrate derivatives is also discussed preliminarily.
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Acta Pharmaceutica Sinica Ano de publicação: 2011 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Acta Pharmaceutica Sinica Ano de publicação: 2011 Tipo de documento: Article