An experimental study on gastric adaptation to aspirin in rats / 中华消化杂志

ABSTRACT

ObjectiveTo investigate the gastric adaptation to aspirin in rats. MethodsMucosal in-jury was induced by repeated doses of acidified aspirin (ASA) in rats. Mucosal lessions and necrosis depth were measured. Mucosal contents of epidermal growth factor (EGF) were tested by radioimmunoassay. To test the possible implication of endogenous nitric oxide in gastric adaptation to aspirin. L-Arg, L-NAME and L-Arg +L-NAME were given intravenously 30 minutes before the exposure to ASA. ResultsThe lession areas of gas-tric mucosa in first exposure to ASA was (50.4 ± 6.2)mm2. After repeated dose of ASA, the mucosal lessions were significantly alleviate, P ＜0.01. The mucosal contents of EGF were significantly increased, P < 0.01.The rat mucosa had adaptation to ASA after pretreated L-Arg、L-NAME and L-Arg + L-NAME. The lession areas of the pretreated L-NAME rats were significantly bigger than that of the pretreated L-Arg rats. Conclu-sionGastric mucosa exhibits the ability to adapt to ulcerogenic action of aspirin. After four days repeated doses of ASA, the full adaptation to ASA was achieved. The mechanism of the adaptation was possibly through increased gastric mucosal EGF. NO played a part of role in the gastric adaptation to ASA.