Monitoring on Serum Concentration of Valproic Acid in Patients with Epilepsy and Individual Dosage Regimen / 中国基层医药

ABSTRACT

Objective To explore the monitoring results on serum concentration of valproic acid in 78 patients with epilepsy for promoting the clinical application and improving the curative effect of serum concentration.Methods The serum concentration of valproic acid was determined by fluorescence polarization immunoassay (FPIA). The serum concentration of valproic acid in 78 cases were analyzed,and the clinical efficacy and adverse reaction were observed. Results Among 78 cases, there were 55 cases (70.0%) whose serum concentration were in normal range,21 cases(27.0% ) in low range and 2 cases(3. 0% ) in high range. The clinical effective rate in 50～100mg/L group, ＜ 50mg/L group and ＞ 100mg/L group were 90.9% ,61.9% and 50.0%. The rate of adverse reaction in 50 ～ 100mg/L group, ＜ 50mg/L group and ＞ 100mg/L group were 1. 8%, 9. 5% and 100%.Conclusion There were significant individual differences among patients in serum concentration of valproic acid. Monitoring on serum concentration of valproic acid was the important measure which provide the basis for adopting individualizede administration and ensure the clinical effect and safety in the medical care.