Effects of shuixianzi extracts on lipid regulation and liver protection in hyperlipidemic rats / 中华老年医学杂志

ABSTRACT

Objective To investigate the preventive and therapeutic effects of shuixianzi extracts on hyperlipidemia rats, and on fatty liver pathology. Methods Shuixianzi was homogenized and filtered. Then the filtrate was freeze-dried after centrifugation. The powder was just the extracts of shuixianzi. During the establishment of rat hyperlipidemic model, the extract was given at the same time. At the end of this experiment, the changes of blood lipid and liver pathology were observed. In therapeutic experiments, after the hyperlipidemia model was established, optimal dose of extract was given, then the changes of blood lipid and liver pathology were also observed and the levels of superoxide dismutase (SOD) and malondialdehyde (MIA) were tested. Results In preventive experiments, high dose of extracts of shuixianzi versus negative control could inhlbit both the increase of TC, TG, LDL-C and the drop of HDL-C. [TC (3.23±0.01) vs. (6.56±0.01) mmol/L; TG(2.33±0.01) vs. (4.12±0.02) mmol/L; LDL-C (2.02±0.01) vs. (3.91±0.02) mmol/L; HDL-C (0.98±0.01) vs. (0.76±0.01) mmol/L, all P＜0.01]. At the same time, the extracts could inhibit the pathological changes of fatty liver. In therapeutic experiments, extracts versus control could regulate the serum lipid levels [TC ( 3.67 ± 0.31 ) vs. ( 6.33 ± 0.52 ) mmol/L; TG ( 1.99 ±0.11) vs. (4.08±0.24) mmol/L; LDL-C (1.57±0.12) vs. (3.78±0.14) mmol/L; HDL-C(1.10±0.03) vs. (0.77±0.02) mmol/L, all P＜0.01] and could reverse fatty changes of liver in hyperlipidemic rats. At the same time the extracts versus control could also increase the activity of SOD [(276.3±26.8) vs. (165.4±16.7) U/mg, P＜0.01] and decrease the level of MDA [(3.67±1.23) vs. (7.45±2.33) nmol/mg, P＜0.01]. Conclusions The extracts of shuixianzi could prevent and treat the hyperlipidemia, inhibit the fatty pathological change of liver, and also have the antioxidant function.