Emerging roles of activating transcription factor 2 in cancer / 国际肿瘤学杂志

ABSTRACT

The Activating Transcription Factor 2 (ATF2) mainly regulates gene transcriptions through mediating cellular response to environmental stimulus. Accumulating studies show that ATF2 is involved in tumorigenesis and tumor cell proliferation, differentiation , apoptosis , invasion and metastasis. Activation of ATF2 may promote tumor cells growth, however, there are several studies show that ATF2 might inhibit growth of tumor cell. Further understanding of the role for ATF2 in tumorigenesis might provide novel thinking pathways for tumor etiology and therapy.