Effects of low-concentration heparin sodium on preventing thrombophlebitis in patients with peripherally inserted central catheter / 中华临床营养杂志

ABSTRACT

Objective To explore the effects of low-concentration heparin sodium (LCHS) on preventing thrombophlebitis in patients with peripherally inserted central catheter (PICC). Methods Totally 287 patients who received PICC from 2007 to 2009 in our department were divided into LCHS group ( n = 128 ), in which the patients had no coagulation disorders or other blood diseases and the used drugs were compatible with heparin sodium, and control group ( n = 159). In the LCHS group, LCHS ( 10 U/ml) was used for irrigation and sealing of the catheter with positive pressure. In the control group, 0. 9% normal saline was used for the same procedures. Changes of the clinical manifestations of phlebitis and the values of plasma fibrinogen in both two groups were observed.Results In LCHS group, 21 patients had obvious clinical manifestations of phlebitis, among whom 8 patients met the diagnostic criteria of thrombophlebitis. On the contrary, in control group, 38 patients had obvious clinical manifestations of phlebitis ( P ＜ 0. 05 ), among whom 31 patients met the diagnostic criteria of thrombophlebitis ( P ＜0. 001 ). The changes of plasma fibrinogen were also significantly different between these two groups ( P ＜ 0. 001 ).Conclusion LCHS can prevent thrombophlebitis in patients with PICC who have no coagulation disorder or other blood diseases and the used drugs are compatible with heparin sodium.