Effect of Amniotic Membrane to Reduce Postlaminectomy Epidural Adhesion on a Rat Model
Journal of Korean Neurosurgical Society
;
: 323-328, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-38686
ABSTRACT
OBJECTIVE:
Epidural fibrosis and adhesion are the main reasons for post-laminectomy sustained pain and functional disability. In this study, the authors investigate the effect of irradiated freeze-dried human amniotic membrane on reducing epidural adhesion after laminectomy on a rat model.METHODS:
A total of 20 rats were divided into two groups. The group A did not receive human amniotic membrane implantation after laminectomy and group B underwent human amniotic membrane implantation after laminectomy. Gross and microscopic findings were evaluated and compared at postoperative 1, 3 and 8 weeks.RESULTS:
The amount of scar tissue and tenacity were reduced grossly in group of rats with human amniotic membrane implantation (group B). On a microscopic evaluation, there were less inflammatory cell infiltration and fibroblast proliferation in group B.CONCLUSION:
This experimental study shows that implantation of irradiated freeze-dried human amniotic membrane reduce epidural fibrosis and adhesion after spinal laminectomy in a rat model.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fibrose
/
Cicatriz
/
Síndrome Pós-Laminectomia
/
Fibroblastos
/
Âmnio
/
Laminectomia
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Journal of Korean Neurosurgical Society
Ano de publicação:
2011
Tipo de documento:
Artigo
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