Compare the characteristics of liver damage in tsutsugamushi disease during different periods / 中国基层医药

ABSTRACT

Objective To compare the characteristics of liver damage in tsutsugamushi disease during different periods. Methods Group A contained 56 cases of tsutsugamushi disease admitted from January 1997 to December 2000,of which 21 cases were complicated by liver damage,while group B contained 80 cased of it admitted from January 2006 to December 2009,including 47 cases complicated by liver damage.Comparative analysis were conducted retrospectively for two groups in terms of liver damage. Results The average age of group A(41.1 ± 14.7)years was significantly lower than that of group B(52.9 ± 15.5)years(t=3.014,P <0.01); The incidences of hepatomegaly and splenomegaly in group A were significantly higher than group B(x2=4.675、6.254,both P <0.05)whereas group B had significantly higher incidences of lack of appetite,abdominal distension and jaundice(all P ＜0.05);The values of various liver function in Group B were significantly higher than group A(all P <0.05). Conclusion The incidence of tsutsugamushi disease is increasing in recent years and the liver damage is becoming more severe.