The efficacy of S-adenosy-L-methionine(SAMe) combided with LMWH in the treatment of intrahepatic cholestasis of pregnancy / 中国基层医药

ABSTRACT

Objective To investigate the efficacy of S-adenosy-L-methionine (SAMe) combided with LMWH in the treatment of intrahepatic cholestasis of pregnancy. Methods 47 patients with intrahepatic cholestasis of pregnancy were divided into two groupsA group(n = 21)received a combination of SAMe and LMWH,B group(n = 26)received only SAMe.The symptom of itching and serum biochemical indexes,including TBA,TB,ALT,and AST were observed after 7days,and the pregnancy outcome between the two groups were compared after delivery. Results All the patients had a significant improvement in pruritus and TBA,TB,ALT,and AST(P ＜0.01＝.After 7 days,there were significant differences in prurits,FBA,AST,ALT,in receiving combination of SAMe and LMWH comparing with received SAMe alone(P ＜0.05＝.The incidence of amniotic fluid pollution was significantly different between the two groups(P＜0.01＝. Conclusion In women with intrahepatic cholestasis of pregnancy,combination of SAMe and LMWH were safe and efficient in the near future.