Tumor necrosis factor-related apoptosis-inducing ligand and its receptors in lung cancer therapy / 国际肿瘤学杂志

ABSTRACT

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a newly discovered apoptosis-inducing ligand that can induce apoptosis of cancer cells, but not of normal cells, through the activation of multiple signaling transduction pathways. By sensitizing lung cancer cells but not normal cells to apoptosis,TRAIL may become a new strategy for the treatment of lung cancer.