Extra-intestinal manifestations of ulcerative colitis / 中国综合临床

ABSTRACT

Objective To investigate the clinic features of extra-intestinal manifestations ( EM ) of ulcerative colitis (UC) in Chinese patients in Liao ning Province. Methods Two hundred and five UC cases in the First Hospital of China Medical University from Jan. 2002 to Feb. 2007 were reviewed retrospectively. Chi-square test was used to test the difference between groups. Results Skeletal and mouth manifestation were the most frequent extra-intestinal manifestations (6. 83% ). The incidence of parenteral performance in patients less than 40 years old was significantly higher than that in patients more than 40 years old (P <0. 01). There was no significant difference between male and female ( P > 0. 05). Our data showed that the extensive colitis had the highest incidence of extra-intestinal manifestations than of the other two types, LUC and DUC. Most extra-intestinal manifestations presented in UC active period ( P < 0. 05 ). The incidence of extra-intestinal manifestations in severe cases was significantly higher than that in mild cases(P <0. 05). There was a trend of increasing frequency from mild to moderate to severe type cases ( P < 0. 05 ). The occurrence of extra-intestinal manifestations was significantly higher in the group with disease course more than five years than that with less than five years group ( P < 0. 05). Conclusions Extra-intestinal manifestations had a high incidence in UC. The most frequently involved organs were joints, mouth, hepatobiliary, skin and eyes system. The patient could have multiple extra-intestinal manifestations and there was a tendency that EM was more likely occurred among patients in the higher age, active phase, longer course, severity degree of the disease.