Advances in gene expression profiling of breast cancer / 国际肿瘤学杂志

ABSTRACT

Breast cancer should be considered as a family of diseases which are significantly different from each other in molecule level rather than a single disease, and clinical heterogeneity of breast cancer origins from molecular heterogeneity. Gene-expression signatures have been developed based on gene expression profiling of breast cancer, such as the 70-gene signature, 21 -gene signature and intrinsic subtypes of breast cancer. These signatures are valuable and have a good prospect in prognosis predicting and clinical decision of breast cancer.