Neutrophil elastase and leukemia / 国际肿瘤学杂志

ABSTRACT

Neutrophil elastase is an important cytotoxicity molecule secreted by neutrophil. It plays a significant role in the development of leukemia. Since this protease can cleave the fusion protein PML-RARα,it may play a role in acute promyelocytic leukemia pathogenesis by facilitating the leukemogenic potential of PML-RARα. Otherwise, this protease might contribute to the clonal dominance of chronic myelognous leukemia by reducing the availability of growth factors for normal hematopoiesis.