Molecular mechanisms involved in EMT regulated invasion and metastasis of pancreatic cancer / 国际肿瘤学杂志

ABSTRACT

Loss of epithelial characteristics and acquisition of a mesenchymal phenotype are the main features of epithelial-mesenchymal transition (EMT). EMT plays an important role in tumor invasion and metastasis through increasing cell migration, invasion and anti-apoptotic capacity. Several mechanisms involved in EMT regulate invasion and metastasis of pancreatic cancer,including cadherin switch, growth factors, transcription factors, microRNA and signaling pathways.