Study on semi-chronic toxicity of cisplatin DLTW 1 on liver and kineys

ABSTRACT

Cisplatin was intravenously injected at the dose of 0.2 mg/kg (equivalent to 1/10 of the maximum non-toxicating dose in mice) four 5-day episodes with the interval of 5 days caused a slight increase in the serum creatinine and urea levels. Similar effects were also observed when cisplatin was IV administered at 0.3 mg/kg/24h for two 5-day episodes with the interval of 10 days. Other mild side effects towards liver and some organs were also observed in about 50% of the mice population. Most of the side effects significantly subdued in both groups 15 days after stopping drug, except damages in hepatic histology, which recovered more slowly