Effect of obstructive sleep apnea syndrome on coronary atherosclerosis plaque / 中华老年医学杂志

ABSTRACT

Objective To investigate the effect of obstructive sleep apnea syndrome (OSAS) on coronary atherosclerosis plaque.Methods A total of 126 old patients with coronary artery disease (CAD) were selected and classified into two groups according to their results of polysomnography and coronary angiographyOSAS plus CAD group (n= 62);no OSAS group (n=64).Peripheral venous blood samples were taken,and the levels of total cholesterol (TC),triglyceride (TG),high-density lipoprotein (HDL-C),low-density lipoprotein (LDL-C),white blood cell counts,neutrophil percent and high sensitive C-reactive protein (hs-CRP) were measured.The cases with coronary lesion,Gensini scores and atherosclerosis plaque were recorded according to coronary arteriography and 64- slice spiral coronary CT angiography.Results The levels of TC,TG and LDL-C were higher in OSAS plus CAD group than in no OSAS group [(5.76+0.85) mmol/L vs.(4.26+0.78) mmol/L,(3.37+1.97) mmol/L vs.(1.72±0.54) mmol/L,(3.65±0.58) mmol/L vs.(2.91±0.58) mmol/L,t= 2.959,3.556,2.165,all P<0.05].The levels of HDL were lower in OSAS plus CAD group than in no OSAS group [(0.86±0.20) mmol/L vs.(1.13±0.14) mmol/L,t=2.545,P<0.05].The white blood cell counts,neutrophil percent and serum hs-CRP levels were higher in OSAS plus CAD group than in no OSAS group (all P<0.05).In OSAS plus CAD group,the prevalence of multivessel disease was 51%,Gensini scores were (23.6±20.7) and coronary atherosclerosis plaques were (67.6 ±9.7),while the prevalence of multivessel disease was 30 %,Gensini scores were (18.9±19.4) and coronary atherosclerosis plaques were (39.3 ± 9.4) in no OSAS group.There were significant differences in the three parameters between the two groups (x2 or t=5.39,2.048,19.001,all P<0.05).Conclusions OSAS is associated with coronary artery disease and can accelerate the formation of coronary atherosclerosis plaque.