Treatment outcomes and prognostic factors of gallbladder cancer patients after postoperative radiation therapy
Korean Journal of Hepato-Biliary-Pancreatic Surgery
;
: 152-156, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-38995
ABSTRACT
BACKGROUNDS/AIMS:
To investigate survival rates and prognostic factors of patients with gallbladder cancer who were treated with surgery and postoperative radiation therapy.METHODS:
Seventeen gallbladder cancer patients who received surgery and postoperative radiotherapy from October 1989 to April 1998 were included in this retrospective study. Five patients had stage II, 8 patients had stage III, and 4 patients had stage IV disease according to the 1997 American Joint Committee on Cancer (AJCC) staging. All patients received > or =40 Gy of postoperative radiotherapy with a daily dose of 2.0 Gy/fraction and 15 patients received concurrent chemotherapy. An analysis was performed for the endpoints of overall and disease-free survival.RESULTS:
Of the 17 patients, 13 had no residual disease (R0), 1 had microscopic residual disease (R1), and 3 had macroscopic residual disease (R2) after surgery. Among patients with no residual disease, 4 had locoregional recurrences during the follow-up period. One patient with microscopic residual disease had local recurrence. The 5-year overall survival rate was 38.2%. The median overall survival time was 21 months and the median disease-free survival time was 12 months. Old age (> or =60 years old), female gender, a high pathological stage (> or =IVA), and the presence of residual disease after surgery were significant prognostic factors for disease-free survival.CONCLUSIONS:
Despite a high proportion of patients with advanced disease and macroscopic residual disease, the prognosis of gallbladder patients who had postoperative radiotherapy is encouraging. Additional investigation to improve the loco-regional control of gallbladder cancer patients with adverse prognostic factors is warranted.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Recidiva
/
Taxa de Sobrevida
/
Estudos Retrospectivos
/
Seguimentos
/
Intervalo Livre de Doença
/
Vesícula Biliar
/
Neoplasias da Vesícula Biliar
/
Articulações
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Hepato-Biliary-Pancreatic Surgery
Ano de publicação:
2011
Tipo de documento:
Artigo
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