Topical and Oral Voriconazole in the Treatment of Fungal Keratitis
Korean Journal of Ophthalmology
;
: 46-48, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-39309
ABSTRACT
We describe two patients with fungal keratitis refractory to standard antifungal therapy whose conditions were managed with voriconazole. The first case is a patient with endophthalmitis and corneal ulcer due to Candida parapsilosis after receiving a corneal transplant. The patient was treated with amphotericin but showed no signs of improvement. Topical voriconazole, oral voriconazole, and intravitreal voriconazole yielded signs of improvement. The second case is a 63-year-old male who underwent a month of empiric treatment with 0.2% topical amphotericin for fungal keratitis but showed no signs of improvement. Treatment was then provided with 1% voriconazole. Both cases showed effective treatment with voriconazole. Voriconazole may be considered as a new method to treat fungal keratitis refractory to standard antifungal therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Soluções Oftálmicas
/
Pirimidinas
/
Triazóis
/
Candidíase
/
Infecções Oculares Fúngicas
/
Administração Oral
/
Seguimentos
/
Córnea
/
Diagnóstico Diferencial
/
Relação Dose-Resposta a Droga
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Journal of Ophthalmology
Ano de publicação:
2009
Tipo de documento:
Artigo
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