Mechanism and Interference therapy of HMGB1 after Ischemia/Reperfusion Injury / 国际外科学杂志
International Journal of Surgery
;
(12): 424-427, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-394452
ABSTRACT
After operations such as organ transplantation or cardiopulmonary bypass complicated with is-chemia/reperfusion injury,activated inflammatory cells can express and secret HMGB1,and cooperate with other inflammation factor to induce tissue damage.The mechanism is HMGB1 actives such receptors as TLRs,RAGE,TM,and NF-κB transcription factor,P38MAPK pathway,induce releasing of HMGB1 itself and other inflammation factors.Different with sepsis,HMGB1 emerges much earlier,lasting longer.Inter-ference therapy of HMGB1 could effectively decrease secretion of HMGB1 after ischemia/reperfusion injury.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
International Journal of Surgery
Ano de publicação:
2009
Tipo de documento:
Artigo
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