The relationship between metabolism of dopamine transporter and levodopa-responsiveness in Parkinon's disease patients of Hohen-Yahr Ⅱ / 中国综合临床

ABSTRACT

Objective To investigate the relationship between metabolism of dopamine transporter and levodopa-responsiveness in patients with Parkinson's disease(PD).Methods Thirteen patients with PD of Hohen-Yahr stage Ⅱ were enrolled in this study.The acute consecutive levedopa/benserazide (50.0/12.5 mg,100.0/25.0 mg,150.0/37.5 mg)tests were used to assess the patients' motor responses.The dopamine transporter binding were assessed with 11C-CFT PET specific in putamen,eaudate nucleus and occipital cortex.The correlation between the improvement of UPDRS Ⅲ and 11C-CFT PET the uptaking capability was analyzed.Results The marked reduction of 11 C-CFT uptake was observed in posterior putamen in patients with PD.The reduction of tracers uptake in posterior putamen contralateral to onset side was more significant than the posterior putamen ipsilateral to onset side (P＜0.01 ).There was significant correlation between 11C-CFF uptake in posterior putamen contralateral to onset side and the improvement of UPDRS motor subscale in test with levedopa/benserazide 100.0/25.0 mg or 150.0/37.5 mg(r=0.513,r=0.572,P＜0.01 ).There was also significant correlation between 11C-CFT uptake in posterior putamen ipsilateral to onset side and the improvement of UPDRS motor subscale in test with levedopa/benserazide 100.0/25.0 mg or 150.0/37.5 mg (r=0.452,r=0.478,P＜0.01 ).There was no correlation between 11C-CFT uptake in basal ganglia and the improvement of UPDTRS motor subscale in test with levedopa/benserazide 100/25mg or 150/37.5 mg(P＞0.05 ).Conclusion There is correlation between metabolism of dopamine transporter and levedopa responsiveness in PD patients of Hoben-Yahr Ⅱ ,which is helpful for the investigation of the pathophysiology.