Development in the study on seed cell resources of liver tissue engineering / 国际生物医学工程杂志

ABSTRACT

Liver tissue engineering is one of the important subjects in tissue engineering field.The major goal of the research is to treat end-stage liver failure and liver based inborn errors of metabolism.Two strategies are usually employedseed cell transplantation for liver tissue repair and regeneration of "liver tissue" consisted of an extraeorporeal bioreactor loaded with cenular component.The seed cells is one of the key ingredient of liver tissue engineering,which include adult hepatocytes,various kinds of liver stem cells,and immortalized cell fines,etc.However,to date,there is no optimal cell resource for application.Many problems should be solved before these cells can be widely used in clinic.This review focuses on the research regarding the seed cells and their potential for the application in liver tissue engineering.