Expression and value of Matriptase and HAI-1 in bladder transitional cell carcinoma / 国际肿瘤学杂志

ABSTRACT

Objective To investigate the expression and clinical significance of Matriptase and HAI-1 in bladder transitional cell carcinoma( BTCC), and to explore their relationship with the clinicopathologieal pa-rameters of BTCC. Methods Expressions of Matriptase and Hal-1 protein in specimens of BTCC and normal bladder tissues were detected by SP method of immunohistochemistry. The results were analyzed in relation to the clinicopathological data. Results The expression of Matriptase and HA1-1 were observed in both normal and tumor tissues of bladder;The protein levels of Matriptase and HAI-1 were significantly higher in normal bladder tissues as compared with BTCC tissues ( P < 0. 05 ) ; a progressive decrease in the protein levels of Hal-1 was observed with increasing of tumor grades (r = -0. 634,P < 0. 001) and clinical stages (r=-0. 521,P < 0. 001 ) ; the protein level of Matriptase was decreased with tumor grade increasing, and was significantly higher in high-grade tissues as compared with moderate and low-grade tissues( P < 0. 05 ) ; Matriptase protein levels showed no significantly difference between different tumor clinical stages ( P > O. 05 ). The correlation co- efficient of Matriptase and HAI-1 in normal tissues was 0. 772(P <0. 001 )and 0. 546 in tumor tissues of blad- der( P < 0. 001 ). Conclusion The abnormal and decreased expressions of Matriptase and HAI- 1 may be im- portant events during the genesis and progression of BTCC in humans; Hal-1 may be used as a new parameterfor assessing the malignancy and prognosis of BTCC; Matriptase protein in BTCC is related with differentiationpromotion, and may be an indicator of differentiation. The correlation between Matriptase and Hal- 1 decreasesin BTCC. The imbalance between HAI-1 and Matriptase may be contributed to the progression of BTCC.