Isoliquiritigenin, a Chalcone Compound, Enhances Spontaneous Inhibitory Postsynaptic Response
Experimental Neurobiology
;
: 163-168, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-39649
ABSTRACT
Isoliquiritigenin (ILTG) is a chalcone compound and shows various pharmacological properties, including antioxidant and anti-inflammatory activities. In recent study, we have reported a novel role of ILTG in sleep through a positive allosteric modulation of gamma-aminobutyric acid type A (GABA(A))-benzodiazepine (BZD) receptors. However, the effect of ILTG in GABA(A)R-mediated synaptic response in brain has not been tested yet. Here we report that ILTG significantly prolonged the decay of spontaneous inhibitory postsynaptic currents (sIPSCs) mediated by GABA(A)R in mouse hippocampal CA1 pyramidal neurons without affecting amplitude and frequency of sIPSCs. This enhancement was fully inhibited by flumazenil (FLU), a specific GABA(A)-BZD receptor antagonist. These results suggest a potential role of ILTG as a modulator of GABAergic synaptic transmission.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Encéfalo
/
Chalcona
/
Flumazenil
/
Transmissão Sináptica
/
Potenciais Pós-Sinápticos Inibidores
/
Ácido gama-Aminobutírico
/
Neurônios
Limite:
Animais
Idioma:
Inglês
Revista:
Experimental Neurobiology
Ano de publicação:
2014
Tipo de documento:
Artigo
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