SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer
Journal of Veterinary Science
;
: 211-213, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-39669
ABSTRACT
Recently, we reported the three wolves cloning with normal karyotype from somatic cells of endangered male gray wolves (Canis lupus), but one wolf had female external genitalia. In this study, we conducted further clinical, histological, and genetic analyses. This cloned wolf had a normal uterus but developed ovotestis. Through molecular analysis of the SRY gene, a mutation in the coding sequence of SRY gene could be excluded as a cause of intersexuality. This is the first report of a cloned wolf with a 78, XY ovotesticular disorder affecting sexual development characterized by bilateral ovotestes.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Lobos
/
Clonagem de Organismos
/
Transtornos Ovotesticulares do Desenvolvimento Sexual
/
Técnicas de Transferência Nuclear
/
Cariotipagem
/
Mutação
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of Veterinary Science
Ano de publicação:
2012
Tipo de documento:
Artigo
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