Relationship between the valence of antibody in pregnant women with blood type O in serum and hemolytic disease of newborn / 中国基层医药

ABSTRACT

Objective To study the reLationship between blood group antibody IgG titer of pregnant women and ABe hemolytic disease of newborn(HDN).Methods Blood group antibody IgG titem of 2700 pregnant women who is O and Rh positive with a non-O husband were detected.After bom,blood groups,Coomb's test,free antibody and antibody release test were done for those 280 babies who were in high risk of HDN.so that we could understand the relationship between the anlibody IgG level of pregnant women and ABO-HDN.Results The percent of anti-A (B)IgG titer＜64,64,128,256 and≥512 in the 2700 O type pregnant women was 62.4%,16.8%,12.6%,5.8%and 2.4%,respectively.There were 67 babies suffered from HDN in those 280 bahies who had high risk.which accounted for 23.9%.With the anti-A (B)IgG liter was 64,128,256 and≥512,the percent of HND positive was 10.2%,27.8%,45.7% and 50.0%,respectively (P＜0.01).Conclusion There is a positive relationship between blood group antibody IgG liter of pregnant women and ABO-HDN.It is necessary for the pregnant women to detect the level of anti-A(B)IgG.