Association Between Apolipoprotein E Gene Polymorphism and Cerebral Infarction in Chinese Han Population A Meta-Analysis / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
;
(12): 888-893, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-397049
ABSTRACT
Objective:
To systematically review the association between apolipoprotein E (APOE) gene polymorphism and cerebral infarction in Chinese Han population.Methods:
The pertinent literature of the gene polymorphism and the case control studies of cerebral infarction in Chinese Han population were researched comprehensively by combined application of 5 effective retrieval approaches. The odds ratio (OR) of the genotype distribution in cerebral infarction group and control group were calculated.Results:
A total of 1986 patients with cerebral infarction and controls were included in the meta-analysis. After the data were pooled, the OR values of ApoE ε2/ε3, ApoE ε3/ε3, ApoE ε2/ε4, ApoE ε3/ε4, and ApoE ε4/ε4 were 0. 59 (95% CI, 0.44-0. 79), 0. 52 (95% CI, 0. 40-0.69), 2.00 (95% CI, 1.22-3.28), 2.77 (95% CI, 1.60-4.81 ), and 4. 66 (95% CI, 1.61-13.48), respectively.Conclusions:
ApoE ε2/ε4, ApoE ε3/ε4 and ApoE ε4/ε4 genotypes are the risk factors of cerebral infarction. ApoE ε2/ε3 and ApoE ε3/ε3 genotypes are the protective factors of cerebral infarction.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo observacional
/
Fatores de risco
/
Revisões Sistemáticas Avaliadas
Idioma:
Chinês
Revista:
International Journal of Cerebrovascular Diseases
Ano de publicação:
2008
Tipo de documento:
Artigo
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