Relationship between NF-kB and pancreatic cancer / 国际外科学杂志
International Journal of Surgery
; (12): 615-618, 2008.
Article
em Zh
| WPRIM
| ID: wpr-398762
Biblioteca responsável:
WPRO
ABSTRACT
NF-κB is a nuclear transcription factor with multiple adjustion. The activation of NF-κB can occur by three different mechanisms. The multiple NF-κB activation pathways are important due to the large number of genes that are regulated by NF-κB and their effects on cancer cells. These gene products can promote growth and tumori-genesis, inhibit apoptosis, allow metastasis and invasion, promote angingenesis, and cause chemoresistance. All of these roles in pancreatic cancer make NF-κB a promising target in treatment. Therefore, inhibiting the activity of NF-κB becomes a hot spot and novel idea of preventing and treating pancreatic cancer.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
International Journal of Surgery
Ano de publicação:
2008
Tipo de documento:
Article