The expression and significance of E-cadherin and COX-2 in pregnant women with hypertensive disorder complicating / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine
;
(36): 26-28, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-399098
ABSTRACT
Objective To evaluate expression of E-cadherin and COX-2 in placentas of hypertensive disorder complieating pregnancy,and study the relationship between them.Method The E-cadherin and COX-2 of twenty-one cases gestational hypertension,along with 17 cases preeclampsia,and 20 cases normal pregnancy placentas were investigated by immunohistochemistry.Results The expression of E-cadherin was significantly higher and the expression of COX-2 was lower in preeclampsia cases than that in normal pregnancy(P<0.01).The expression of E-cadherin negatively correlated with the expression of COX-2 (r=-0.371.P<0.05).Conclusions The alteration of E-cadheria and COX-2 in placentas are correlated with preeelampsia.The up-reguhted expression of E-cadherin and down-regulated expression of COX-2 maybe regulated by the same factor.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Postgraduates of Medicine
Ano de publicação:
2008
Tipo de documento:
Artigo
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