Olfactory function test in Parkinson's disease / 中华神经科杂志

ABSTRACT

Objective To study the offactory function test in Parkinson' s disease(PD), in order to promote the diagnosis of the PD. Methods Subjects included 95 middle-aged volunteers and 37 Pdpatients. A subjective olfactometry with T&T olfactometer was performed in all volunteers and patients.Olfactory event related potentials with isoamyl acetate were obtained in all volunteers and patients. Results The T&T olfactometer Results for the 2 sides were 4.6±1.1,4.4±1.2 in PD patients older than 70 years old and 3.9±1.7, 4.0±1.7 in those, respectively; while the data were 0.4±0.9,0.4±0.9 in volunteers older than 70 years, were 0.5±0.8,0.5±0.8 younger than 70 years old. There was a significant differencein T&T olfactometer Results between PD and volunteers (t=15.246,15.378,8.664,8.776, P<0.01). TheP2 latencies were respectively (734.9±143.2), (696.1±165.9) ms for the 2 sides in PD older than 70years, and (730.5±159.4), (719.5±159.2) ms in PD younger than 70 years;while they were (547.9±65.0), (558.5±56.3) ms, and (523.3±61.9), (526.8±62.0) ms in volunteers younger than 70 years.There was a significant difference in P2 latency between PD and volunteers (t = -3.940, -3.750,- 7. 514, - 8.205,P<0.01). Conclusions Olfactory dysfunction is an important index in PD. Olfactory function test is an useful method in the diagnosis of PD.