Progression of research of MDR1 single nucleotide polymorphism / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 494-496, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-399604
ABSTRACT
P-glycoprotein(P-gp),the product of multidrug resistance gene MDR1,plays a very significant role in the ADME processes(absorption,distribution,metabolism,excretion)and drug-drug interaction of drugs in human.The magnitude of resistance depends on the expression of MDR1 up-regulated by chemotherapy.DNA sequence differences ale associated with phenotypic variation by various mechanisms,single-nucleotide polymorphisms(SNPs)is the most common of them.Genetic polymorphisms of MDR1 are associated with alteration in P-gp expression and function in different ethnicities and subjects.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Oncology
Ano de publicação:
2008
Tipo de documento:
Artigo
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