Indicators of predicting sensitivity of preoperative concurrent radiochemotherapy for rectal cancer / 国际肿瘤学杂志

ABSTRACT

Preoperative radiochemotherapy for locally advanced rectal cancer can improve local control rate obviously and ameliorate survival rate for pathologically complete response. However the clinical response is different among patients. Recently, clinical study and basic research results suggest survivin, p53/p21, telom-erase, growth hormone receptor(GHR), ku70, Bax, Bcl-2, Ki67 and vascular endothelial growth factor (VEGF) are related to the sensitivity of preoperative concurrent radiochemotherapy. They can be used to pre-dict sensitivity of preoperative radiochemotherapy.