Apoptin induces apoptosis in tumor cells / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 330-333, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-400476
ABSTRACT
Apoptin,a chicken anemia virus-derived protein.selectively induces apoptosis in trans-formed or tumor cells but not in normal cells.The tumor specificity of apoptin is thought to be related to its cel-lular localization.The apoptin-induced apoptosis is p53-independent and can not be blocked by overexpressionof Bcl-2.But activation of Caspase-3 is essential for apoptin-induced apoptosis.These features make apoptin a potential candidate as a novel therapeutic and diagnostic tool in cancer treatment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Oncology
Ano de publicação:
2008
Tipo de documento:
Artigo
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