Cationic Trypsinogen Gene Mutation in Patients with Chronic Idiopathic Pancreatitis / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 41-46, 2004.
Artigo
em Coreano
| WPRIM
| ID: wpr-40062
ABSTRACT
BACKGROUND/AIMS:
Mutation of Cationic trypsinogen gene is clearly associated with hereditary pancreatitis and plays an important role in the pathogenesis of pancreatitis. According to literature, this mutation is occasionally occurred in patients with pancreatitis in Western countries and Japan. The aim of this study was to find out whether the mutation was observed in Korean patients with chronic idiopathic pancreatitis.METHODS:
Peripheral blood samples of 11 patients with chronic idiopathic pancreatitis were collected consecutively, and DNA was extracted from the samples. Polymerase chain reaction was performed in exon 2 and 3 of cationic trypsinogen gene. Then, DNA products were purified and sequenced.RESULTS:
The mutation was not found in exon 2 and 3 of cationic trypsinogen gene in these patients.CONCLUSIONS:
There was no cationic trypsinogen mutation in Korean patients with chronic idiopathic pancreatitis. Further large sampled cohort study is needed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pancreatite
/
Tripsinogênio
/
Resumo em Inglês
/
Tripsina
/
Reação em Cadeia da Polimerase
/
Doença Crônica
/
Mutação
Tipo de estudo:
Estudo observacional
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2004
Tipo de documento:
Artigo
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