Effects of genomic HLA-DR compatibility on long-term survival in first-cadaver kidney transplants / 中华器官移植杂志
Chinese Journal of Organ Transplantation
; (12): 109-111, 2000.
Article
em Zh
| WPRIM
| ID: wpr-400756
Biblioteca responsável:
WPRO
ABSTRACT
Objective To study the effect of genomic HLA-DR compatibility on long-term survival in renal transplantation.Methods A retrospective study was performed on 518 first-cadaver renal transplants by using genotyping technique.Results More than 10%recipients shared HLA-DR matching at DNA level.half of 1 DR mismatches.The recipients with HLA-DR matched transplants showed a significant decrease of acute rejection episodes and a smooth recovery of early renal function as compared with those of DR mismatching kidneys.The 1 to 5 year-person survival rate was increased by 17%to 37.7% (P<0.01)respectively.Multivariate analysis of 10 variables by Cox regression model revealed that DR mismatching was the most important factors influencing the long-term graft survival.Conclusion Genomic HLA-DR compatibility had a significant impact on long-term survival of first-cadaver kidney transplantation.
Texto completo:
1
Índice:
WPRIM
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Organ Transplantation
Ano de publicação:
2000
Tipo de documento:
Article