Comparison of vascular complications between adults latent autoimmune diabetes and type 2 diabetes / 中国综合临床

ABSTRACT

Objective To compare the prevalence of microvascular and macrovascular complications between adult latent autoimmune diabetes(LADA)and type 2 diabetic subjects.Methods A cross-sectional study was performed in 203 LADA(GADA positive)and 203 T2DM(GADA negative)subjects matched with age,gender and duration as well as family history of diabetes.Parameters of microvascular(albuminuria、eyeground microscopy or fundus fluorescence photography,electromyogram)and macrovascular complications(electrocardiogram,blood pressure,blood lipid,body mass index)as well as blood sugar were compared.Results ①Microvascular complicationsCompared with T2DM,LADA cases showed higher prevalence of diabetic nephropathy(39.9%vs.28.6%,P＜0.05)and similar prevalence in diabetic neuropathy and retinopathy(P＞0.05).②Macrovascular complicationsLADA cases presented lower prevalence of hypertension(38.9%vs.55.7%,P＜0.01),lower prevalence of metabolic syndrome (33.0%vs.45.3%,P＜0.01＝,but similar orevalence of coronarv heart disease (CHD) and erebral infarction(CVD)(P＞0.05).Conclusion LADA patients present less metabolic syndrome,hypertension and more diabetic nephropathy compared with T2DM.