Relationship of genetic polymorphisms of heme oxygenase-1, tumor necrosis factor-α, human β-defensin -1 with chronic obstructive pulmonary disease / 中华老年医学杂志
Chinese Journal of Geriatrics
;
(12): 333-336, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-400902
ABSTRACT
Objective To investigate the relationship of smoking, the gene polymorphisms of heine oxygenase-1, tumor necrosis factor-α, and human β-defensin-1 with chronic obstructive pulmonary disease (COPD). Methods A case-control study was held to compare the genotype frequency distribution of heine oxygenase-1, tumor necrosis factor-α, human β-defensin-1 by PCR -RFLP method and to analyze the relationship among them. Results The L allele gene frequency of heine oxygenase-1 was 23.44% in COPD group and 10.71% in control group with significant difference(P<0.05). The heterogenesis gene frequency of tumor necrosis factor-α in COPD group and control group were 18. 24% and 7.53% (P<0.01). The heterogenesis gene frequency of human β-defensin-1 was 14.28% in COPD group and 5.00% in control group with significant difference(P<0. 01). Conclusions Smoking is a risk factor for COPD. Genetic polymorphisms of heme oxygenase-1, tumor necrosis factor-α, human β-defensin-1 are related with the development of COPD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Idioma:
Chinês
Revista:
Chinese Journal of Geriatrics
Ano de publicação:
2008
Tipo de documento:
Artigo
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