Change of prolactin in SD rats with experimental autoimmune thyroiditis / 中华内科杂志

ABSTRACT

Objective　To verify the effect of prolactin (PRL) on the development and progression of experimental autoimmune thyroiditis (EAT) in SD rats and the inhibitive effect of bromocriptine (BRC) on the development of EAT. Methods　SD rats were injected with BRC to inhibit the development of EAT and the change of PRL were observed. Results　High level of serum PRL was found in the EAT rats ［(8.70±0.42)μg/L, P＜0.01 vs. control (6.46±0.67) μg/L］ , and there was also high levels of thyroid autoantibodies (thyroglobulin antibody, thyroid peroxidase antibody) . However, in rats receiving BRC, the levels of thyroid autoantibodies decreased as the PRL level declined (5.30±0.81)μg/L and the thyroid lesions were mild. Conclusion　Hyperprolactinemia plays a role in the development of EAT and control of the hyperprolactinemia with BRC may afford therapeutic benefit.