Effect of rheumatoid arthritis associated HLA-DRβ1 subtypes on protein kinase A signaling / 中华内科杂志
Chinese Journal of Internal Medicine
;
(12): 19-21, 2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-402201
ABSTRACT
Objective To investigate the impact of rheumatoid arthritis (RA)-associated HLA-DRβ1*0401,*0402,*0403 and*0404 subtypes on protein kinase A (PKA) signaling. Methods To detect the activities of adenylate cyclase (AC), cAMP and PKA in transfectants expressing rheumatoid arthritis-associated HLA-DRβ1 subtypes and their mutants. Results The levels of AC, cAMP and PKA of HLA-DRβ1*0401 and*0404 transfectants were significant lower than that of HLA-DRβ1*0402 and*0403 transfectants (P<0.01). The mutant HLA-DRβ1*0403 tranfectants expressing DRRAE or QRRAA secreted lower levels of PKA, cAMP and AC (P<0.01). Conclusion RA-associated HLA-DRβ1*0401 and*0404 expression suppressed intracelluar PKA signaling pathway, and may mediate abnormal intracellular signaling in rheumatoid arthritis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Internal Medicine
Ano de publicação:
2001
Tipo de documento:
Artigo
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