Massive Identification of Cancer-Specific Nucleic Acid Ligands
Genomics & Informatics
;
: 77-80, 2005.
Artigo
em Inglês
| WPRIM
| ID: wpr-40261
ABSTRACT
Targeting of complex system such as human cells rather than biochemically pure molecules will be a useful approach to massively identify ligands specific for the markers associated with human disease such as cancer and simultaneously discover the specific molecular markers. In this study, we developed in vitro selection method to identify nuclease-resistant nucleic acid ligands called RNA aptamers that are specific for human cancer cells. This method is based on the combination of the cell-based selection and subtractive systematic evolution of ligands by exponential enrichment (SELEX) method. These aptamers will be useful for cancer-specific ligands for proteomic research to identify cancer-specific molecular markers as well as tumor diagnosis and therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteômica
/
Diagnóstico
/
Aptâmeros de Nucleotídeos
/
Técnica de Seleção de Aptâmeros
/
Ligantes
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Genomics & Informatics
Ano de publicação:
2005
Tipo de documento:
Artigo
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