Significant association between SNPs in IRF6 and non-syndromic cleft lip with or without cleft palate in West China / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6): 227-231, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-403301
ABSTRACT
Objective:
To study the association between the rs2013162 and rs2235375 polymorphisms in IRF6 and risk of NSCL/P in west Chinese population.Methods:
The study group consisted of 332 NSCL/P patients, their parents (289 mothers, 243 fathers and 206 complete families), and 174 controls. PCR-RFLP method was used to identify genotypes and both case-parent and case-control designs were carried out on samples from west China.Results:
There were significant differences in the frequency distributions of both genotypes and alleles when cases were compared with control infants at the rs2235375(P<0.01, P<0.01 respectively). We found strong evidence of over-transmission of the G allele at rs2235375 in cleft case-parent trios(P<0.01). Five specific haplotypes showed significant over-and under-transmission.Conclusion:
These results suggest IRF6 variants play a role in NSCL/P in west Chinese populations.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Journal of Practical Stomatology
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS