Effect of extrinsic vascular endothelial growth factor (VEGF) on the viability of rat skin flap received radiotherapy / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6): 169-172, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-403340
ABSTRACT
Objective:
To observe the relationship between the vascular endothelial growth factor (VEGF) and the survival of flap in the rat back which received radiotherapy.Methods:
Forty Wistar rats were divided into four groups. A 3×4 cm~2 full thickness dorsal flap with pedicle was prepared at the posterior end. The skin flaps were given~(60)Co radiotherapy in the 2, 4, 6 day postoperation. Group A was given of VEGF in the third, fifth, seventh day. Group B was given a high quantity of VEGF. Group C was the control of Group A,Group D was the control of Group B. Control groups received normal saline.Results:
Pathological observation revealed that the survival of flap and blood vessel lumen diameter of group A were higher than that of group B(P<0.05). Group A showed remarkable difference compared with group C(P<0.01). Group B showed remarkable difference compared with group D(P<0.05). Results of fluorescence staining and SDH examination showed that three times injection had better results than one time injection.Conclusion:
Three times injection of VEGF has better effect on the viability of rat skin flap than one time injection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Practical Stomatology
Ano de publicação:
2010
Tipo de documento:
Artigo
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