Study on the Correlation of Spiral CT Features with Expression of E-cadherin in Peripheral Lung Cancer / 实用放射学杂志
Journal of Practical Radiology
;
(12): 24-27, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-403453
ABSTRACT
Objective To investigate the correlation of spiral CT features with expression of E-cadherin(E-cad) in peripheral lung cancer.Methods Spiral CT scans were performed in 58 patients with peripheral lung cancer confirmed by pathology.Expression of E-cad in 58 cases were detected with SP immunohistochemical techniques.Spiral CT findings were compared with expression of E-cad.Results The abnormal expression of E-cad was showed in 32 cases(55.17%).The positive rates of E-cad expression were 40.63% in I-II cell differentiation group and 73.08% in III-IV cell differentiation group,and the difference was significant(P<0.05).The abnormal expression of E-cad was associated with the CT features,such as lymph node metastasis,pleural invasion and the size of tumor(P<0.05),but not the cavity sign,spicular sign and vessel convergence sign(P>0.05).Conclusion E-cad gene over expression may play an important role in the pathogenesis and CT appearances of lung cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Practical Radiology
Ano de publicação:
2010
Tipo de documento:
Artigo
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