A case of systemic sclerosis associated with gastric cancer / 대한내과학회지

ABSTRACT

We report the case of a 32-year-old woman who experienced stiffness and thickening of skin and Raynaud's phenomenon. Anti-nuclear antibody, anti-SSA antibody and anti-Scl 70 antibody were positive. Clinical manifestations and laboratory investigations were appropriate to systemic sclerosis (SSc). The patient was also diagnosed as Bormann type III advanced gastric cancer on gastrofiberoscopy. Several reports suggested the association of SSc with various malignant carcinomas. They noted that the most frequent types were lung cancer and skin cancer. Stomach cancer was rarely reported in association with systemic sclerosis. The association between SSc and gastric cancer is not clear, but several mechanisms are proposed in several studies.