Hemodynamic changes in cirrhosis rats after orthotopic liver transplantation / 西安交通大学学报(医学版)

ABSTRACT

Objective To investigate the hemodynamic changes in cirrhosis rats after orthotopic liver transplantation. Methods The cirrhosis model was constructed in 50 healthy male SD rats by intraperitoneal and subcutaneous injection with carbon tetrachloride (CCl_4), and induced by drinking alcohol solution for 10 weeks. Orthotopic liver transplantation with two-cuff technique was adopted to these rats. The hemodynamic changes were observed. Results Cirrhosis model was constructed in 36 rats, 26 of which then received liver transplantation. Finally 12 cirrhosis rats survived, and hemodynamics of portal vein were observed. The statistical analysis revealed that the portal venous pressure decreased significantly after the operation compared with pretransplant [(1.60±0.10)kPa vs. (1.70±0.25)kPa, P<0.05]; the portal vascular resistance increased significantly [(7.55±1.02)mL/min vs. (6.15±0.88)mL/min, P<0.05]; however, the portal venous flow decreased obviously[(11.84×10~(-2)±2.51×10~(-2))kPa/(mL·min)vs.(16.29×10~(-2)±2.40×10~(-2))kPa/(mL·min),P<0.05-.Conclusion The hemodynamics of cirrhosis rats ameliorate after rthotopic liver transplantation.