Application of common spinal injury models and bone marrow mesenchymal stem cells transplantation in the treatment of spinal cord injury / 中国组织工程研究

ABSTRACT

The pathophysiological mechanism of spinal cord injury is very complex.In order to find out the clinical treatment for spinal cord injury,the suitable design of a spinal cord injury experimental model is critically important to explore the mechanism in treatment the spinal cord injury,by which the transplantation of bone marrow mesenchymal stem cells could be conducted,Nowadays,several methods have already existed on the design of spinal cord injury experimental model,including contused model,tension model,compression model,cutting model or resorption model,and ischemia model,and the way of bone marrow mesenchymal stem cells transplantation,including call suspension stereotaxis injection,lumbar puncture cell suspension injection,and intravenous cell suspension injection.The possible mechanisms of bone marrow mesenchymal stem cells in treatment of spinal cord injury were as follows① bone marrow mesenchymal stem cells could move to the damage department and differentiate into neural cell phenotype;② bone marrow mesenchymal stem cells could play the role of bridge-mediation;③ bone marrow mesenchymal stem cells could inhibit the apoptosis of the nerve cells after transplantation.Animal experiments proved that there are broad prospects of clinical application of bone marrow mesenchymal stem calls for the treatment of spinal cord injury.