Polymorphism of HLA-A and HLA-B in pre-eclampsia / 北京大学学报(医学版)
Journal of Peking University(Health Sciences)
; (6): 418-425, 2009.
Article
em Zh
| WPRIM
| ID: wpr-405899
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WPRO
ABSTRACT
Objective: To investigate the association between the polymorphism of HLA-A, HLA-B genes and pre-eclampsia. Methods: HLA-A, HLA-B genotyping was performed by polymerase chain reaction sequence-specific primer (PCR-SSP) in 119 preeclampsia patients, 117 normal pregnant women and their neonates. Results: The study showed that 16 HLA-A and 39 HLA-B alleles were obtained in pre-eclamptic patients and normal pregnant women. 15 HLA-A and 37 HLA-B alleles were obtained in their neonates. No significant difference was found in maternal or neonatal HLA-A, HLA-B alleles be-tween pre-eclampsia group and control group (Pc>0. 05). The frequencies of HLA-A11, HLA-A24,HLA-B13, HLA-B14, HLA-B15, HLA-B52 maternal/fetus genetic assoications were significantly different between pre-eclampsia group and control group (P<0. 05). Conclusion: Some HLA-A, HLA-B maternal/fetus special bindings may be associated with the susceptibility or protective of pre-eclampsia.
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WPRIM
Idioma:
Zh
Revista:
Journal of Peking University(Health Sciences)
Ano de publicação:
2009
Tipo de documento:
Article