Role of activating transcription factor 2 in the growth of mandible condyle chondrocytes / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6): 459-462, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-405934
ABSTRACT
Objective:
To study the role of activating transcription factor 2 (ATF-2) in the growth of mandibular condyle cartilage.Methods:
Primary chondrocytes of condyle were cultured. Expression plasmid of ATF-2 and plasmid bcl-2 promoter were transfected into chondrocytes. Luciferase assay and Western blot were used.Results:
The absence of ATF-2 in mandibular condyle chondrocytes resulted in a decline in bcl-2 promoter activity, reduction in bcl-2 protein level.Conclusion:
The results strongly imply that ATF-2 is required for adequate bcl-2 expression, and play a significant role in controlling growth plate chondrocyte progression.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Practical Stomatology
Ano de publicação:
2009
Tipo de documento:
Artigo
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