Clinical value of urinary neopterin in monitoring of pulmonary tuberculosis drug resistance in 112 children / 国际检验医学杂志

ABSTRACT

Objective To investigate the clinical value of urinary neopterin in monitoring of pulmonary tuberculosis drug resistance in 112 children.Methods Slip diffusion method was applied to performing tuberculosis drug resistance test. According to the detecting results, 112 children with active pulmonary tuberculosis were divided into resistance group(n=48) and non-resistance group(n=64). 50 healthy children were enrolled as healthy control group. ELISA was employed to measure the urinary neopterin level for all subjects.Results There were statistical differences in urinary neopterin levels among resistance group, non-resistance group and healthy control group. The urinary neopterin level was more elevated in patients with pulmonary tuberculosis than that of healthy controls;while, the urinary neopterin level was much higher in resistance group than that of non-resistance group.Conclusion Not only does the measurement of urinary neopterin play a assisted role in diagnosis of pulmonary tuberculosis in children, but also it is of prewarning value in monitoring of children pulmonary tuberculosis drug resistance. As a non-invasive, rapid, simple and sensitive preliminary screening index, urinary neopterin is worthy of spreading and applying in clinic.